M. Fatih Okcu, M.D., M.P.H.
6621 Fannin St., MC 3-3320
Houston, TX 77030
Associate Professor, Department of Pediatrics, Section of Hematology-Oncology, Baylor College of Medicine
Staff Member, Texas Children's Hospital
M.D. and Residency, Istanbul University Medical School, Istanbul, Turkey
M.P.H. and Residency, The University of Texas Health Science Center
Fellowship, The University of Texas M.D. Anderson Cancer Center
American Board of Pediatrics
American Board of Pediatrics-Hematology/Oncology
Clinical Special Interests:
Soft Tissue Sarcoma
Dr. Okcu’s area of research interest is molecular cancer epidemiology. His studies aim to explain the differences in outcomes in patients with the same cancer type, treated with similar therapies by genetic polymorphisms that modify therapy modalities. He has been studying the relationship between glutathione s-transferase polymorphisms and survival, and occurrence of adverse events secondary to treatment in adults and children with brain tumors. He is the director of research in the long-term survivor program and now has ongoing studies exploring the relationship between genetic polymorphisms and neurocognitive impairments in children who are survivors of acute leukemia and brain tumors.
Sanbao Ruan, M. Fatih Okcu, Jiang Ping Ren, Paul Chiao, Michael Andreeff, Victor Levin and Wei Zhang. Overexpressed WAF1/Cip1 renders glioblastoma cells resistant to chemotherapy agents 1,3-Bis(2-chloroethyl)-1-nitrosurea and Cisplatin: Cancer Research, 1998; 58 :1538 -1543
Sanbao Ruan, M. Fatih Okcu, Rey-Chen Pong, Michael Andreeff, Jer-Tsong Hsieh, and Wei Zhang. Attenuation of WAF1/Cip1 expression by an antisense adenovirus expression vector sensitizes glioblastoma cells to apoptosis induced by chemotherapeutic agents BCNU and Cisplatin: Clinical Cancer Research, 1999; 5:197-202
M.F. Okcu, S. Despa, M. Chorosy, S.G. Berrak, A. Cangir, N. Jaffe, and R.B. Raney. Synovial Sarcoma in children and adolescents: Thirty three years of experience with multimodal therapy: Medical and Pediatric Oncology, 2001; 37: 90-96
Richard J Andrassy, M Fatih Okcu, Simona Despa and R Beverly Raney. Synovial sarcoma in children: Surgical lessons from a single institution and review of the literature: J Am Coll Surg 2001; 192:305-313
Mehmet Fatih Okcu, Karen J. Goodman, Susan E. Carozza, Nancy S. Weiss, Keith D. Burau, W. Archie Bleyer, and Sharon P. Cooper. Birth weight, ethnicity and occurrence of cancer in children: a population-based, incident case-control study in the State of Texas: Cancer Causes and Control, 2002; 13:595-602
Okcu MF, Munsell M, Treuner J, Pappo A, Cain A, Ferrari A, Casanova M, Ozkan A, and Raney RB. Synovial Sarcoma of Childhood and Adolescence: A Multicenter, Multivariate Analysis of Outcome of 219 Patients: Journal of Clinical Oncology, 2003; 21:1602-1611
M. Fatih Okcu, W. Mark Roberts, Dennis A. Johnston, Maia V. Ouspenskaia, Victor Z. Papusha, Mark A. Brandt, and Theodore F. Zipf. Risk classification at the time of diagnosis differentially affects the level of residual disease in children with B-precursor acute lymphoblastic leukemia after completion of therapy. Leukemia Research, 2003; 27:734-750
Ken Aldape, M. Fatih Okcu, Melissa Bondy and Margaret Wrench: Molecular Epidemiology of Glioblastoma Multiforme. (Cancer J, 2003;9:99-106)
M. Fatih Okcu, Mano Selvan, Li-E Wang, Linda Stout, Rodrigo Erana, Gladstone Airewele, Phyllis Adatto, Kenneth Hess, Qingyi Wei, Francis Ali-Osman, Morris Grooves, Al Yung, Victor Levin and Melissa Bondy: Glutathione S-Transferase Polymorphisms and Survival in Primary Malignant Glioma (Clinical Cancer Research,2004;10:2618-2625)
Russell HV, Hicks J, Okcu MF, Nuchtern JG. CXCR4 expression in neuroblastoma primary tumors is associated with clinical presentation of bone and bone marrow metastases. (Journal of Pediatric Surgery, 2004;39:1506-1511
Okcu MF, Wang RY, Bueso-Ramos C, Schober W, Weidner D, Andrassy R, Blakely M, Russell H, Ozkan A, Kuttesch J , Andreeff M, Chan KW, and Ater J. Flow cytometry and fluorescence in situ hybridization to detect residual neuroblastoma cells in bone marrow. Pediatric Blood and Cancer, 2005;45:787-795
Suell MN, Bezold LI, Okcu MF, Mahoney, Jr, DH, Shardonofsky, F and Mueller BU. Increased pulmonary artery pressures among adolescents with sickle cell disease. J Pediatr Hematol Oncol, 2005;27:654-658.
Wang L, Qei Q, Wang LE, Aldape KD, Cao Y, Okcu MF, Hess KR, El-Zein R, Gilbert MR, Woo SY, Prabhu SS, Fuller GN, Bondy ML. Survival prediction in patients with glioblastoma multiforme by human telomerase genetic variation. J Clin Oncol, 2006;24:1627-1632.
Vasudevan SA, Russell HV, Okcu MF, Burlingame SM, Liua ZJ, Yang J, Nuchtern JD. Neuroblastoma-derived secretory protein messenger RNA levels correlate with high-risk neuroblastoma. Journal of Pediatric Surgery (2007) 42, 148– 152
Nathan PC, Patel SK, Dilley K, Goldsby R, Harvey J, Jacobsen C, Kadan-Lottick N, McKinley K, Millham AK, Moore I, Okcu MF, Woodman CL, Brouwers P, Armstrong FD. Guidelines for identification of, advocacy for, and intervention in neurocognitive problems in survivors of childhood cancer. Arch Pediatr Adolesc Med, 2007;161:798-806.
Krull KR, Brouwers P, Jain N, Zhang L, Bomgaars L, Dreyer Z, Mahoney D, Bottomley S, Okcu MF. Folate pathway genetic polymorphisms are related to attention disorders in childhood leukemia survivors. J Pediatr. 2008;152:101-105.
Paulino AC, Okcu MF. Rhabdomyosarcoma. Current Problems Cancer 2008;32:1-36.
Curtis AE, Okcu MF, Chintagumpala M, Teh BS, Paulino AC. Local Control After Intensity-Modulated Radiotherapy for Head-and-Neck Rhabdomyosarcoma. Int J Radiat Oncol Biol Phys. 2008 May 21.
Schroeder TM, Chintagumpala M, Okcu MF, Chiu JK, Teh BS, Woo SY, Paulino AC. Intensity-modulated radiation therapy in childhood ependymoma. Int J Radiat Oncol Biol Phys. 2008;71:987-93.
Sonabend RY, McKay SV, Okcu MF, Yan J, Haymond MW, Margolin JF. Hyperglycemia during induction therapy is associated with increased infectious complications in childhood acute lymphocytic leukemia. Pediatr Blood Cancer. 2008;51:387-92.
Krull KR, Okcu MF, Potter B, Jain N, Dreyer Z, Kamdar K, Brouwers P. Screening for neurocognitive impairment in pediatric cancer long-term survivors. J Clin Oncol. 2008;26:4138-43.