Gastrointestinal Stromal Tumors Center (GIST)
Why choose the GIST Center at Texas Children's Cancer Center?
Pediatric gastrointesintal stromal tumors (GIST) are rare in children and adolescents and little is known about how to best treat them. To optimize the care of these patients, children should be treated in specialized centers where the staff are familiar and have expertise in the pathologic, radiographic and therapeutic aspects of these rare and challenging tumors.
The Texas Children's Cencer Center provides a unique environment in which patients with pediatric GISTs can recieve highly specialized care from physicians of various disciplines including surgery, pathology, diagnostic imaging, genetics and oncology.
We also offer a variety of support services and diagnostic procedures including social workers, psychologists, access to CT, MR, PET, IMRT and the most advanced radiotherapy techniques to optimize the care of your child. Finally, the Texas Children's Cancer Center has a large molecular oncology, cell biology and developmental therapeutics program, which is focused on developing better treatments and understanding of gastrointestinal stromal tumors.
How to contact the GIST Center
During business hours:
Alberto Pappo, M.D.
During non-business hours:
Call the hospital operator (832-824-1000) and ask for the hematology/oncology fellow on-call.
Meet the Physicians and Staff of the GIST Center
Alberto Pappo, M.D., Clinical Director - Hematology/Oncology
Jed Nuchtern, M.D. - Surgery
Paul Guillerman, M.D. - Radiology
Susan Blaney, M.D. - Developmental Therapeutics
Ching Lau, M.D., Ph.D. - Genomics
Arnold Paulino, M.D. - Radiation Therapy
David Kornguth, M.D. - Radiation Therapy
Sharon Plon, M.D., Ph.D. - Genetics
John Hicks, M.D., Ph.D., D.D.S. - Pathology
Selected References on Pediatric GIST
Hayashi Y., Okazaki T., Yamataka A., Yanai T., Yamashiro Y., Tsurumaru M., Kajiyama Y., Miyano T. Gastrointestinal stromal tumor in a child and review of the literature: Pediatric Surgery International, 21(11): 914-917, 2005. View here
Kuroiwa M., Hiwatari M., Hirato J., Suzuki N., Tsuchida Y., Shimada A., Shitara T., Taki T., Hayashi Y. Advanced-stage gastrointestinal stromal tumor treated with imatinib in a 12-year-old girl with a unique mutation of PDGFRA: Journal of Pediatric Hematology/Oncology, 40(11): 1798-1801, 2005. View here
O'Sullivan M.J., McCabe A., GIllett P., Penman, I.D., MacKinlay G., Pritchard J. Multiple gastric stromal tumors in a child without syndromic association lacks common KIT or PDGFRalpha mutations: Pediatric and Developmental Pathology, 8(6): 685-689, 2005. View here
Prakash S., Sarran L., Socci N., DeMatteo R.P., Eisenstat J., Greco A.M., Maki R.G., Wexler L.H., LaQuaglia M.P., Besmer P., Antonescu C.R. Gastrointestinal stromal tumors in children and young adults: a clinicopathologic, molecular, and genomic study of 15 cases and review of the literature: Journal of Pediatric Hematology/Oncology, 27(4): 179-187, 2005. View here
Price V.E., Zielenska M., Chilton-MacNeil S., Smith C.R., Pappo A.S. Clinical and molecular characteristics of pediatric gastrointestinal stromal tumors: Pediatric Blood Cancer, 45(1): 20-24, 2005. View here
Cypriano M.S., Jenkins J.J., Pappo A.S., Rao B.N., Daw N.C. Pediatric gastrointestinal stromal tumors and leiomyosarcoma: Cancer, 101(1): 39-50, 2004. View here
Kerr J.Z., Hicks M.J., Nuchtern J.G., Saldivar V., Heim-Hall J., Shah S., Kelly D.R., Cain W., Chintagumpala M.M. Gastrointestinal autonomic nerve tumors in the pediatric population: a report of four cases and a review of the literature: Cancer, 85(1): 220-230, 1999. View here